[email protected] By Kathryn Stephenson and Bisola Ojikutu June 26, 2020 Reprints Women and Black patients are poorly represented in clinical trials, analysis finds @HarvardCFAR First OpinionCovid-19 vaccine research must involve Black and Latinx participants. Here are 4 ways to make that happen Yet past experience shows that Covid-19 vaccine trials will likely have challenges meeting enrollment targets like these. In 2019, for example, the Food and Drug Administration approved 11 new cancer drugs based on clinical trials that enrolled just 4% of Black participants, despite the fact that Black individuals account for 13% of the U.S. population and have the highest death rate for most cancers.advertisement Everyone in medical research shares the responsibility to promote equitable representation in Covid-19 vaccine trials. Here are some ways we can do this:Step 1. Acknowledge the problem. We must recognize the importance of enrolling Black and Latinx participants in these studies, even in the context of unprecedented rapid enrollment. Studies must report the demographics of trial enrollment while they are ongoing.Step 2. Provide appropriate funding to trial sites to support diversity initiatives. It takes money to translate informed consent forms, reimburse participants for transportation, staff clinics on weekends and nights, and advertise in a broad array of neighborhoods and media outlets. It also takes money and institutional will to build a diverse research workforce that reflects affected communities and is representative of the country as a whole.Step 3. Address research mistrust by engaging communities now, at the beginning, not when it’s time to share the final results. This means investigators need to meet with local stakeholders in Black and Latinx communities, host webinars and virtual town halls, do interviews on community radio, and put themselves out there on social media.Step 4. Pay people back for trusting in the medical research community. We need to make any successful Covid-19 vaccine that comes out of this herculean research effort accessible to everyone in this country — regardless of race, ethnicity, or the ability to pay for it. The fair and transparent distribution of an effective Covid-19 vaccine is paramount.Vaccines can be transformative. They have the potential to provide medical shelter against deadly diseases like Covid-19, allowing communities to safely emerge from this pandemic and rebuild.The recent protests against racism in the United States are calls to medicine and science too: Black and Latinx communities must be a part of the critical endeavor to develop a vaccine for Covid-19.Kathryn Stephenson is the director of the clinical trials unit in the Center for Virology and Vaccine Research and an infectious disease physician at Beth Israel Deaconess Medical Center in Boston. Bisola Ojikutu is the director of the Community Engaged Research Program in the Harvard Center for AIDS Research and an infectious disease physician at Brigham and Women’s Hospital and Massachusetts General Hospital. @k_stephensonMD [email protected] People wait to be tested for Covid-19 at a mobile testing station in a public school parking area in Compton, Calif. ROBYN BECK/AFP via Getty Images Beyond words: medical institutions must act to support Black lives Related: About the Authors Reprints Related: Kathryn Stephenson Clinical trials also establish the safety and effectiveness of new interventions, and there is no guarantee that the effects of an intervention will be the same across populations. Contemporary medical studies point to disparities in response rates to pharmacological therapies by race and ethnicity. No one knows for sure if such variances are products of the socioeconomic realities faced by trial participants, a variety of environmental factors, or genetics, but they are real. The development of a Covid-19 vaccine is progressing at an incredible pace, breaking down barriers to the invention, manufacture, and testing of potential vaccine candidates. The Department of Health and Human Services says it aims to have “substantial quantities of a safe and effective vaccine available for Americans by January 2021.”To achieve this goal, each of the five leading Covid-19 vaccine candidates will need to be tested in approximately 30,000 people — a total of 150,000 research participants in the next six months. This will be a massive and unprecedented undertaking.Equally unprecedented is the opportunity that Covid-19 vaccine development presents to break down barriers to the engagement of Black and Latinx individuals in clinical trials research. Ideally, vaccine trials should include participants from communities that have the highest risk of infection. In the case of Covid-19, those at-risk communities are disproportionately Black and Latinx. To match local demographics of Covid-19, Black or Latinx individuals would need to comprise up to 40% of vaccine trial participants nationwide.advertisement Most clinical trials are designed to enroll racially and ethnically diverse groups of participants and honestly aim to do that. But it’s a hard goal to achieve. The hours that clinics are open are too limited for people of color whose employers prohibit taking off work; study budgets don’t always pay for interpreters and translations that would facilitate participation by non-English speakers; study protocols often exclude individuals with chronic illnesses like diabetes and hypertension, which disproportionately impact people of color.The pressure to enroll participants and quickly accumulate data can be intense, especially in a pandemic, often eclipsing the goal of equitable representation.Another barrier to equitable clinical trial participation is the pervasive structural racism that is intricately woven into the fabric of our society. The U.S. has a shameful history of unethical experimentation on Black men and women, from experimental surgeries performed without anesthesia on enslaved Black women to the misappropriation of cervical tissue from Henrietta Lacks and the infamous Tuskegee syphilis study. This history has led to understandable and pervasive mistrust of clinical research. It is no wonder that Black and Latinx patients often say to us, “I don’t want to be a guinea pig in your experiments.”Layered on top of this are strong anti-immigrant and sometimes xenophobic views that keep Latinx individuals and others who weren’t born in the U.S. away from contact with health care institutions, including research groups.A recent survey conducted by the Pew Research Center demonstrates how this sordid history and ongoing structural inequity could affect clinical trial participation: Even if a Covid-19 vaccine were available today and proven effective, only 54% of Black adults would be willing to take it, compared to 74% of white adults. The statistics would likely be equally dismal for participation in Covid-19 vaccine trials. Bisola Ojikutu Tags CoronavirusresearchVaccines
PlayStation 5 enjoys second biggest month so far | UK Monthly Boxed ChartsMarch 2021 can’t match March 2020, but it was still a strong month for physical game salesChristopher DringHead of Games B2BFriday 9th April 2021Share this article Recommend Tweet SharePlayStation 5 was the best-selling console in the UK for a second month in a row.Sony’s new console enjoyed its second biggest month so far, and it’s already overtaken PlayStation Vita, Wii U and Dreamcast in terms of sales in the UK.This is based on GfK Entertainment data.There was new stock of Xbox Series X and S as well, which saw a boost in sales for Microsoft’s new machines. It means that for the first time in years, Nintendo Switch was in third-place for the month.However, Switch sales continue to trend upwards. Year-to-date, the console is up 13.6% over the first three months of 2020, not bad for a machine now entering its fifth year on the market.March 2020 was a significant month for physical games and consoles sales in the UK due to the start of the COVID-19 lockdown, and as a result the comparisons for 2021 don’t look great. 217,268 games consoles (panel retail data, not upweighted) were sold in the UK over the four weeks to April 3rd, 2021, which is an impressive figure but still down 7.6% over the same period in 2020. In terms of boxed software, just over one million games were sold during March 2021, which is down 20% over the same period in 2020. Nintendo Switch dominated the charts for March, with Animal Crossing: New Horizons the best-selling game of the month 12 months after it launched, followed by Super Mario 3D World + Bowser’s Fury at No.3, Monster Hunter Rise at No.3, Mario Kart 8: Deluxe at No.5.The one non-Switch game in the Top Five is PlayStation-exclusive Spider-Man: Miles Morales at No.4.Related Jobs3D Artist – Mobile Studio – Midlands UK & Europe Big PlanetProducer Indie Game Studio France UK & Europe Big PlanetSenior C++ Unreal Programmer – PC and Console Studio – Austria South East Big PlanetDiscover more jobs in games One area of the industry that did grow year-on-year was the accessories market. 886,091 accessories were sold during March, which is a rise of 9% over February, and almost 14% up over March 2020. So far this year, accessory sales are up 36.7% with 2.57 million headsets, controllers and more being sold through retail.Sony is the no.1 accessories provider for March, just ahead of Turtle Beach. This was driven by accessories for PlayStation 5, including the DualSense controller (the No.1 accessory of the month), the Pulse 3D headset (No.5) and the DualSense Charging Station (No.7).Here is the GfK January Top 20 UK Boxed Games PositionTitle1Animal Crossing: New Horizons (Nintendo)2Super Mario 3D World + Bowser’s Fury (Nintendo)3Monster Hunter Rise (Capcom)4Spider-Man: Miles Morales (Sony)5Mario Kart 8: Deluxe (Nintendo)6Super Mario 3D All-Stars (Nintendo)7FIFA 21 (EA)8Minecraft: Switch Edition (Nintendo/Mojang)9Call of Duty: Black Ops Cold War (Activision)10Grand Theft Auto 5 (Rockstar)11Ring Fit Adventure (Nintendo)12Assassin’s Creed: Valhalla (Ubisoft)13Minecraft Dungeons (Microsoft)14Super Mario Odyssey (Nintendo)15Luigi’s Mansion 3 (Nintendo)16Just Dance 2021 (Ubisoft) 17Watch Dogs Legion (Ubisoft)1851 Worldwide Games (Nintendo)19Pokémon Sword (Nintendo)20LEGO Harry Potter Collection (Warner Bros)Celebrating employer excellence in the video games industry8th July 2021Submit your company Sign up for The Publishing & Retail newsletter and get the best of GamesIndustry.biz in your inbox. Enter your email addressMore storiesSpecialEffect joins Best Places To Work Awards as charity partnerUS event deadline is coming upBy Christopher Dring 21 hours agoResident Evil: Village is the third biggest PS5 launch so far | UK Boxed ChartsBut physical sales down over previous Resident Evil gamesBy Christopher Dring 23 hours agoLatest comments Sign in to contributeEmail addressPasswordSign in Need an account? Register now.
Spencer Platt/Getty Images(NEW YORK) — Firefighters from New Jersey and New York to Indiana are pushing through the brutally cold temperatures to do their jobs.In New Jersey, a monstrous fire broke out Wednesday night at a paper mill in Elmwood Park. The fire was so massive people that people flying into Newark International Airport could see it.More than 150 firefighters from at least 10 towns descended on the scene. The temperature hovered near 4 degrees, with a wind chill of negative 12.The fire was under control early Thursday morning, officials said. No one was injured, officials added.In New York City, where temperatures plunged to 2 degrees, the coldest of the year, a 5-alarm fire in Brooklyn posed “challenging conditions for our firefighters,” the New York City Fire Department tweeted. No injuries were reported.In the Philadelphia area, where the temperature was 5 degrees, firefighters had to use a blow torch to thaw out frozen fire hydrants.Firefighters also struggled in the Midwest.In Cameron, Wisconsin, fire chief Mitch Hansen looked more like an ice sculpture after fighting a fire in minus 50 degree wind chills.And in Plainfield, Indiana, frozen crews fought an unrelenting blaze at a trash facility, leaving fire equipment coated with ice.“The weather and large amount of trash is making this a daunting task,” the Plainfield Fire Territory said on Facebook. Copyright © 2019, ABC Radio. All rights reserved.
Photo taken on May 10, 2018 shows the Chinese-built Maputo Bridge in Maputo, capital of Mozambique. (Xinhua/Wang Teng) Photo taken on May 10, 2018 shows the Chinese-built Maputo Bridge in Maputo, capital of Mozambique. (Xinhua/Wang Teng)The southern African nation Mozambique is set to launch in June the Chinese-built Maputo Bridge and Link Road.The project, once open, is expected to quickly become the nation’s key international passageway linking it southward to South Africa.The bridge is expected to significantly ease passenger and cargo transport between Mozambique and South Africa, boosting trade and tourism development.Engineer Bai Pengyu says the bridge will also drive the economic development of various sectors in the underdeveloped Katembe district, including land development, commercial services, logistics, and modern industries.The bridge, which will be the largest suspension bridge in Africa, is part of a larger project that includes a set of access roads on both banks and other roads, including one leading to Ponta do Ouro, a beach area near the border with the province of Natal, in South Africa, which is over 170 kilometres long.The project is just one part of Chinese President Xi Jinping’s larger China-Africa policy and is aimed at strengthening China-Africa ties as well as stronger political mutual trust.The Maputo Bridge and Link Roads project officially opens to traffic on June 25th.
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Related Will Heath/NBC(NEW YORK) — Melissa McCarthy returned to Saturday Night Live this weekend to reprise her role as White House Press Secretary Sean Spicer, and as she did last week, she portrayed him as eccentric, short-tempered and disrespectful to journalists.Alec Baldwin also returned to SNL this weekend, marking his 17th time as the show’s host, though he only portrayed President Donald Trump in one sketch.During the show’s cold open, McCarthy’s gum-chewing Spicer ruled over a press briefing, and again used props to explain a point to reporters — at one point, using a male soldier doll, a white Barbie doll and a dark Moana doll to illustrate who would and wouldn’t get in the U.S. under President Trump’s immigration plan. McCarthy’s Spicer also spoofed the real-world issue of retailers dropping Ivanka Trump’s clothing and accessories collection. “…There [was] some light terrorism this week, when Nordstrom decided to stop selling Ivanka Trump’s line of clothing and accessories,” she said, the showed how Spicer/McCarthy was wearing not only one of Ivanka’s bangles, but also a pair of heels: “And don’t even get me started on her shoes!” Spicer shouted.Kate McKinnon also briefly appeared during the skit as newly-minted Attorney General Jeff Sessions, who took considerable criticism for his alleged racist views. “We all know there are two kinds of crime,” McKinnon/Sessions drawled. “Regular, and black,” at which point McKinnon/Spicer quickly stepped in and ushered Sessions offstage.In another sketch, McKinnon’s Kellyanne Conway broke into CNN anchor Jake Tapper’s apartment — a la Fatal Attraction — to complain that he refused to have her on his show. “I just want to be a part of news, Jake,” she said seductively, ultimately attacking Tapper with a knife.In another sketch, Baldwin’s Trump appeared in the TV court show The People’s Court to try and reinstate his immigration ban, bringing Russian President Vladimir Putin, again played by cast member Beck Bennett, as a character witness. And toward the end of the show, a sketch focused on cast member Leslie Jones’ ambitions to play Trump, complete with her donning a dark suit, red tie and blond wavy hair. While SNL producer Lorne Michaels refused to allow it, Jones stormed out of 30 Rock, still dressed as Trump. A limo pulled up and a woman portraying Melania Trump cracked the window and said, “Donald? What are you doing out here?” Jones then got shrugged and then got into the limo with her.Copyright © 2016, ABC Radio. All rights reserved. Powered by WPeMatico